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KMID : 0360720130260010006
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Journal of the Korean Society Traumatology
2013 Volume.26 No. 1 p.6 ~ p.13
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Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
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Jang Gui-Sang
Lee Jae-Hyuk
Kim Kyu-Seok
Jo You-Hwan
Lee Joong-Eui
Lee Kyoung-Bun
Park Chan-Jong
Kang Chang-Woo
Lee Soo-Hoon
Kim Joong-Hee
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Abstract
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Purpose: Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated.
Methods: Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed.
Results: Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased.
Conclusion: Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.
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KEYWORD
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Paraquat, Sulforaphane, Lipid peroxidation
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